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N,N – Dimethyltryptamine or DMT primary site of activation is the serotonergic receptor 5-HT2A. How ever this is not DMT’s sole binding site. DMT appears to affect neutral networks within the prefrontal cortex, sensory-associated cortices, salience network, and default mode network. Increasing their global functional connectivity. Though more research is necessary to fully understand the neural effects of DMT, it appears to decrease higher-order cognitive functioning.
